Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-5-15
pubmed:abstractText
The targeted removal of damaged proteins by proteolysis is crucial for cell survival. We have shown previously that the Lon protease selectively degrades oxidized mitochondrial proteins, thus preventing their aggregation and cross-linking. We now show that the Lon protease is a stress-responsive protein that is induced by multiple stressors, including heat shock, serum starvation, and oxidative stress. Lon induction, by pretreatment with low-level stress, protects against oxidative protein damage, diminished mitochondrial function, and loss of cell proliferation induced by toxic levels of hydrogen peroxide. Blocking Lon induction with Lon siRNA also blocks this induced protection. We propose that Lon is a generalized stress-protective enzyme whose decline may contribute to the increased levels of protein damage and mitochondrial dysfunction observed in aging and age-related diseases.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/ES 03598, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-14, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-15A1, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-16, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-17, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-18, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-19, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-20, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-21, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-22, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-22S2, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-23, http://linkedlifedata.com/resource/pubmed/grant/R01 ES003598-24
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-10339569, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-10852912, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-11294851, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12014829, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12082077, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12086680, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12198491, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12391597, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12459471, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12657466, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12750521, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12752449, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-12972288, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-1355616, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-14739292, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-15004229, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-15560797, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-15582322, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-15683722, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-15692048, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-15803138, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-15840721, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-15937182, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-16428295, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-16432145, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-16487045, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-16487047, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-16487049, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-16487050, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-16487055, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-16574110, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-16677792, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-17300997, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-17418790, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-17420247, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-17502481, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-18095366, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-3036875, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-6330035, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-6436819, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-8561505, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-8577761, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-8660387, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-8806733, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-8886803, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-9212076, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-9485316, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-9685417, http://linkedlifedata.com/resource/pubmed/commentcorrection/19439239-9869323
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-4596
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1042-8
pubmed:dateRevised
2011-8-5
pubmed:meshHeading
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