|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
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pubmed:dateCreated |
2009-5-29
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|
pubmed:abstractText |
Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1464-3405
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:day |
15
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
3225-8
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pubmed:meshHeading |
pubmed-meshheading:19435666-Animals,
pubmed-meshheading:19435666-Apoptosis,
pubmed-meshheading:19435666-Cells, Cultured,
pubmed-meshheading:19435666-Cerebral Cortex,
pubmed-meshheading:19435666-Enzyme Inhibitors,
pubmed-meshheading:19435666-Humans,
pubmed-meshheading:19435666-Indazoles,
pubmed-meshheading:19435666-Neurodegenerative Diseases,
pubmed-meshheading:19435666-Neurons,
pubmed-meshheading:19435666-Neuroprotective Agents,
pubmed-meshheading:19435666-Pyrazoles,
pubmed-meshheading:19435666-Sphingosine,
pubmed-meshheading:19435666-Structure-Activity Relationship
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|
pubmed:year |
2009
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|
pubmed:articleTitle |
Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons.
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|
pubmed:affiliation |
Graduate Institute of Pharmaceutic Chemistry, China Medical University, Taichung 404, Taiwan.
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pubmed:publicationType |
Journal Article
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