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rdf:type |
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lifeskim:mentions |
umls-concept:C0020205,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0058516,
umls-concept:C0220781,
umls-concept:C0268563,
umls-concept:C0439611,
umls-concept:C0441655,
umls-concept:C0567416,
umls-concept:C0962179,
umls-concept:C1707689,
umls-concept:C1883254
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pubmed:issue |
12
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pubmed:dateCreated |
2009-5-29
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pubmed:abstractText |
A series of artemisinin-vinyl sulfone hybrid molecules with the potential to act in the parasite food vacuole via endoperoxide activation and falcipain inhibition was synthesized and screened for antiplasmodial activity and falcipain-2 inhibition. All conjugates were active against the Plasmodium falciparum W2 strain in the low nanomolar range and those containing the Leu-hPhe core inhibited falcipain-2 in low micromolar range.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-10353642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-10887194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-11716777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-11849701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-12076181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-12499184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-15163175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-15192087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-15664655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-17482816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-17665872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-17979807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-18336340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-18774792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-7650671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-7895837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-8807047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-8893847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19435664-9925304
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3229-32
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pubmed:dateRevised |
2011-5-16
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pubmed:meshHeading |
pubmed-meshheading:19435664-Animals,
pubmed-meshheading:19435664-Antimalarials,
pubmed-meshheading:19435664-Antiprotozoal Agents,
pubmed-meshheading:19435664-Artemisinins,
pubmed-meshheading:19435664-Cysteine Endopeptidases,
pubmed-meshheading:19435664-Dipeptides,
pubmed-meshheading:19435664-Drug Design,
pubmed-meshheading:19435664-Parasitic Sensitivity Tests,
pubmed-meshheading:19435664-Plasmodium falciparum,
pubmed-meshheading:19435664-Structure-Activity Relationship,
pubmed-meshheading:19435664-Sulfones
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pubmed:year |
2009
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pubmed:articleTitle |
Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.
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pubmed:affiliation |
iMed.UL, Faculty of Pharmacy, University of Lisbon, Av Prof. Gama Pinto, 1649-003, Portugal.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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