Source:http://linkedlifedata.com/resource/pubmed/id/19435661
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2009-5-29
|
| pubmed:abstractText |
A series of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives 2a-r were synthesized as HIF-1alpha inhibitors. Among the compounds synthesized, compound 2k was found to be a potent inhibitor against HIF-1alpha accumulation under hypoxic condition and inhibited the hypoxia-induced HIF-1 transcriptional activity in HEK293 cells (IC(50)=7.2 microM). Furthermore, compound 2k suppressed the hypoxia-induced secretion of VEGF in HeLa cells (IC(50)=15 microM).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3166-9
|
| pubmed:meshHeading |
pubmed-meshheading:19435661-Anoxia,
pubmed-meshheading:19435661-Cell Line,
pubmed-meshheading:19435661-HeLa Cells,
pubmed-meshheading:19435661-Humans,
pubmed-meshheading:19435661-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:19435661-Inhibitory Concentration 50,
pubmed-meshheading:19435661-Phenylurea Compounds,
pubmed-meshheading:19435661-Structure-Activity Relationship,
pubmed-meshheading:19435661-Transcription, Genetic,
pubmed-meshheading:19435661-Vascular Endothelial Growth Factor A
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1alpha inhibitors.
|
| pubmed:affiliation |
Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171-8588, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|