Source:http://linkedlifedata.com/resource/pubmed/id/19431214
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2009-7-6
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| pubmed:abstractText |
This study was to investigate the clinical significance and virologic factors of occult hepatitis B virus (HBV) infection in hepatocellular carcinoma (HCC) patients without hepatitis B surface antigen (HBsAg) or anti-hepatitis C virus (non-B, non-C) in Taiwan. Serum HBV DNA (occult HBV) was detected in 90 of 222 non-B, non-C HCC patients and 24 of 300 non-B, non-C controls without HCC. Of 90 occult HBV-infected HCC patients, the sequences of HBV pre-S/surface, X and enhancer II/core promoter/precore genes were analyzed from 40 patients. Direct sequencing of such genes was also performed in 24 non-B, non-C controls without HCC and 40 HBsAg-positive HCC controls. Compared with non-B, non-C controls without HCC, non-B, non-C subjects with HCC had significantly higher prevalence of occult HBV (p < 0.0001). Moreover, M1I and Q2K in pre-S2 gene and G1721A were more common in occult HBV-infected patients with HCC than in those without HCC. Compared with the HBsAg-positive HCC controls, occult HBV-infected HCC patients had higher frequencies of M1I and Q2K in pre-S2 gene, G185R and S210N in surface gene, A36T and A44L in X gene, and G1721A in enhancer II gene, and had lower rates of pre-S deletions and A1762T/G1764A, A1846T, G1896A and G1899A in core promoter/precore genes. Multivariate analysis showed Q2K in pre-S2 gene, G1721A and A1846T were independent factors for occult HBV-infected HCC. Our study suggested that the virological factors of HBV related to HCC were different between occult HBV-infected and HBsAg-positive patients. The G1721A, M1I and Q2K in pre-S2 gene may be useful viral markers for HCC in occult HBV carriers.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1097-0215
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
125
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
621-9
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| pubmed:meshHeading |
pubmed-meshheading:19431214-Adult,
pubmed-meshheading:19431214-Aged,
pubmed-meshheading:19431214-Amino Acid Sequence,
pubmed-meshheading:19431214-Asian Continental Ancestry Group,
pubmed-meshheading:19431214-Base Sequence,
pubmed-meshheading:19431214-Biological Markers,
pubmed-meshheading:19431214-Carcinoma, Hepatocellular,
pubmed-meshheading:19431214-Case-Control Studies,
pubmed-meshheading:19431214-DNA, Viral,
pubmed-meshheading:19431214-Female,
pubmed-meshheading:19431214-Genetic Variation,
pubmed-meshheading:19431214-Genotype,
pubmed-meshheading:19431214-Hepatitis B,
pubmed-meshheading:19431214-Hepatitis B Core Antigens,
pubmed-meshheading:19431214-Hepatitis B Surface Antigens,
pubmed-meshheading:19431214-Hepatitis B virus,
pubmed-meshheading:19431214-Humans,
pubmed-meshheading:19431214-Liver Neoplasms,
pubmed-meshheading:19431214-Male,
pubmed-meshheading:19431214-Middle Aged,
pubmed-meshheading:19431214-Molecular Sequence Data,
pubmed-meshheading:19431214-Multivariate Analysis,
pubmed-meshheading:19431214-Polymerase Chain Reaction,
pubmed-meshheading:19431214-Prevalence,
pubmed-meshheading:19431214-Promoter Regions, Genetic,
pubmed-meshheading:19431214-Taiwan
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| pubmed:year |
2009
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| pubmed:articleTitle |
A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan.
|
| pubmed:affiliation |
Department of Internal Medicine, Division of Hepatogastroenterology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|