Linked Life Data

19431078

Source:http://linkedlifedata.com/resource/pubmed/id/19431078

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-5-11
pubmed:abstractText
Rheumatoid arthritis (RA) was originally thought to be a T-helper (Th)1-, not a Th2-, associated disorder; however, it currently is unclear whether RA is a Th1- and/or Th17-mediated disease, and what the contributions of these T-cell subsets are in the pathogenesis of RA. Results from studies using different arthritis models have demonstrated that IL-17-producing T-cells are the dominant cell type in the development of arthritis. In addition, a critical role of the IL-23/IL-17 axis in the progression to chronic destructive arthritis has been demonstrated. Interestingly, Th1 and Th17 cells both may have unique pathogenic potential, and the recent insights into T-cell plasticity may change the understanding of the role of T-cell subsets in chronic autoimmune diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
2040-3429
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
452-62
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The IL-12/IL-23 axis and its role in Th17 cell development, pathology and plasticity in arthritis.
pubmed:affiliation
Erasmus Medical Center, Departments of Rheumatology and Immunology's Gravendijkwal 230, 3015 CE Rotterdam, the Netherlands.
pubmed:publicationType
Journal Article, Review