Linked Life Data

19429385

Source:http://linkedlifedata.com/resource/pubmed/id/19429385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-5-11
pubmed:abstractText
This study was aimed at evaluating spatial function in subjects with Williams syndrome by using the radial arm maze task and comparing their spatial abilities with those of mental age-matched control subjects. Two different paradigms were administered: the free-choice version for analyzing the aspects linked mainly to procedural and mnesic components, the forced-choice version for disentangling components linked to spatial working memory from the procedural ones. The findings evidenced a deficit in the acquisition of procedural competences as well as in the spatial memory processes in Williams subjects. In the free-choice paradigm, they performed worse than control subjects on all parameters analyzed. Namely, they needed more time to complete the task, did not collect all rewards, exhibited low values of the spatial span as well as low percentages of correct visits, and displayed a reduced use of the most efficient exploration strategies. Even in the forced-choice paradigm, Williams subjects made a number of errors significantly higher than control subjects. The marked impairment in spatial information processing is discussed on the light of neuro-anatomical alterations reported in Williams subjects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1873-474X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-13
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Spatial competences in Williams syndrome: a radial arm maze study.
pubmed:affiliation
IRCCS Santa Lucia Foundation, Rome, Italy. laura.mandolesi@uniparthenope.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't