Linked Life Data

19429184

Source:http://linkedlifedata.com/resource/pubmed/id/19429184

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-5-11
pubmed:abstractText
It is generally considered that iodine deficiency is the single most common cause of preventable mental retardation (MR) and brain damage. The SLC26A4 gene is expressed at the apical surface of thyrocytes and its product forms an efficient iodide-trapping mechanism. To investigate whether variability in the SLC26A4 gene influences the risk of iodine-deficiency based MR, we undertook an association study between SLC26A4 and MR. Participants were recruited from a relatively isolated and traditionally iodine-deficient region with a high prevalence of MR. The SNPs we selected from the dbSNP and HapMap were identified using ARMS-PCR and sequencing methods. Singular-locus and haplotype association analysis indicated no association between the SLC26A4 gene and MR (p>0.05). The negative results suggest that the SLC26A4 gene has no measurable impact on iodine-deficiency based MR. In view of the characteristics of our samples, our study may provide a good reference for research into the transport features of pendrin in the thyrocyte apical surface.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1872-7972
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
457
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
An association study of the SLC26A4 gene in children with mental retardation.
pubmed:affiliation
Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't