Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-5-11
pubmed:abstractText
Monoamines are implicated in the modulation of adult hippocampal neurogenesis in depression models and following chronic antidepressant treatment. Given the key role of Sonic hedgehog (Shh) in adult neurogenesis, we examined whether monoaminergic perturbations regulate the expression of Shh or its co-receptors Smoothened (Smo) and Patched (Ptc). Combined depletion of both serotonin and norepinephrine with para-chlorophenylalanine (PCPA) resulted in a significant decrease in Smo and Ptc mRNA within the dentate gyrus subfield of the hippocampus. However, selective depletion of serotonin, using the serotonergic neurotoxin 5,7-dihyrdroxytryptamine (5,7-DHT), or norepinephrine, using the noradrenergic neurotoxin DSP-4, did not alter expression of Shh and its co-receptors, Smo and Ptc. Acute treatment with the monoamine releasing agent, para-chloroamphetamine (PCA) significantly upregulated Smo mRNA within the dentate gyrus. However, acute or chronic treatment with pharmacological antidepressants that modulate monoaminergic neurotransmission did not regulate Shh cascade expression. These results indicate that robust changes in monoamine levels can regulate the expression of the Shh signaling cascade in the adult rodent brain.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-10362289, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-10510184, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-10574978, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-11124987, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-11576188, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-11731473, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-12453065, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-12469128, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-12838272, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-12907793, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-12971894, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-15604099, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-16197497, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-16460708, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-16604184, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-1685125, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-17401725, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-17435610, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-17785179, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-18045164, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-18603367, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-2867921, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-3725191, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-575425, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-6513731, http://linkedlifedata.com/resource/pubmed/commentcorrection/19429033-9818625
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1872-7972
pubmed:author
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
453
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
190-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Monoaminergic regulation of Sonic hedgehog signaling cascade expression in the adult rat hippocampus.
pubmed:affiliation
Department of Biological Sciences, Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400005, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't