Linked Life Data

19428985

Source:http://linkedlifedata.com/resource/pubmed/id/19428985

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2009-5-11
pubmed:abstractText
Cholesterol is an essential component of eukaryotic cell membranes with an important role in signal transduction. Although cholesterol can operate to auto-regulate its own disposal via gene transcriptional mechanisms, glucose also binds to the same cholesterol-binding transcription factors to regulate gene expression. Different sterol binding proteins bind different lipids to regulate both lipid homeostasis and antigen presentation. This mini-review examines the recently reported new functions of cholesterol binding proteins in cholesterol homeostasis, function and trafficking, and explores the molecular mechanisms whereby sterol sensors respond to glucose and other ligands to regulate diverse cellular functions in metabolism. Several new models are proposed from studies on a range of sterol binding proteins including Insig, SCAP, LXR, HMG-CoAR, NPC1 and NPC2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1872-8057
pubmed:author
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
303
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
New functions of cholesterol binding proteins.
pubmed:affiliation
Department of Immunology, Monash University Central Clinical School, Prahran, Victoria, Australia. jun-ping.liu@med.monash.edu.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't