Linked Life Data

19428702

Source:http://linkedlifedata.com/resource/pubmed/id/19428702

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-5-11
pubmed:abstractText
We investigated the role of aquaporin-4 (AQP4), a water channel expressed in glial cells, in neural activity mediated morphological changes observed in brain slice preparation. Changes in flavoprotein fluorescence (FF) and infrared light scattering (LS) signals were measured before and after repetitive stimulation of layer VI in rostral somatosensory cortical slices taken from AQP4 knockout (KO) and wild-type (WT) mice. Changes in FF, which reflect neural aerobic activities, were comparable for the two groups in all cortical layers. However, changes in LS signals, which are indicative of cell swelling, were significantly decreased in layer I of AQP4 KO mice compared to that of WT mice. We conclude that AQP4 likely plays a significant role in neural activity-dependent glial swelling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1872-8111
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
208-12
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice.
pubmed:affiliation
Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Japan; Department of Neurophysiology, Brain Research Institute, University of Niigata, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't