| pubmed-article:19428110 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C1706474 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C2239176 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C0019728 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C1420556 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C1424530 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19428110 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19428110 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19428110 | pubmed:dateCreated | 2009-5-20 | lld:pubmed |
| pubmed-article:19428110 | pubmed:abstractText | Malignant transformation of hepatocytes is frequently associated with upregulation of HLA-A expression. Currently there is no information available regarding the mechanisms underlying this phenotypic change. We investigated HLA-A expression in 165 paraffin embedded tissues and 21 fresh tissues from liver cancer patients. Utilizing truncated HLA-A promoter-reporter constructs and gel-shift assay we had identified the regulatory elements and transcription factors required for HLA-A upregulation. 54% of the paraffin embedded tissues showed increased HLA-A expression in their cancerous part. 43% of the fresh liver cancer tissues had increased HLA-A complex expression with the HLA-A heavy chain gene demonstrating the highest level of upregulation (62%). Enhanced HLA-A expression in the liver cell lines QGY7701 and BEL7402 was found to be mediated by binding of interferon regulatory factor 1 (IRF-1) to interferon stimulated response element, and of nuclear transcription factor p65 binding to enhancer A element in the HLA-A promoter of these cell lines. The in vivo relevance of these findings was indicated by the association of the enhanced expression of IRF-1 and accumulation of nuclear p65 with HLA-A upregulation in 8 of the 21 liver cancer lesions investigated. Our results indicated that HLA-A upregulation in liver cancer was mediated by both increased nuclear aggregation of transcription factor p65 and upregulation of transcription factor IRF-1. | lld:pubmed |
| pubmed-article:19428110 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19428110 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19428110 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19428110 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19428110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19428110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19428110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19428110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19428110 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19428110 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19428110 | pubmed:issn | 1872-9142 | lld:pubmed |
| pubmed-article:19428110 | pubmed:author | pubmed-author:RaiS BSB | lld:pubmed |
| pubmed-article:19428110 | pubmed:author | pubmed-author:JinYangY | lld:pubmed |
| pubmed-article:19428110 | pubmed:author | pubmed-author:FerroneSoldan... | lld:pubmed |
| pubmed-article:19428110 | pubmed:author | pubmed-author:XuLianhongL | lld:pubmed |
| pubmed-article:19428110 | pubmed:author | pubmed-author:ZhangJianqion... | lld:pubmed |
| pubmed-article:19428110 | pubmed:author | pubmed-author:XiaMeiM | lld:pubmed |
| pubmed-article:19428110 | pubmed:author | pubmed-author:ShenYuqingY | lld:pubmed |
| pubmed-article:19428110 | pubmed:author | pubmed-author:MiaoFengqinF | lld:pubmed |
| pubmed-article:19428110 | pubmed:author | pubmed-author:ChenAiqinA | lld:pubmed |
| pubmed-article:19428110 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19428110 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:19428110 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19428110 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19428110 | pubmed:pagination | 2045-53 | lld:pubmed |
| pubmed-article:19428110 | pubmed:dateRevised | 2009-6-16 | lld:pubmed |
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| pubmed-article:19428110 | pubmed:meshHeading | pubmed-meshheading:19428110... | lld:pubmed |
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| pubmed-article:19428110 | pubmed:meshHeading | pubmed-meshheading:19428110... | lld:pubmed |
| pubmed-article:19428110 | pubmed:meshHeading | pubmed-meshheading:19428110... | lld:pubmed |
| pubmed-article:19428110 | pubmed:meshHeading | pubmed-meshheading:19428110... | lld:pubmed |
| pubmed-article:19428110 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19428110 | pubmed:articleTitle | IRF-1 and p65 mediate upregulation of constitutive HLA-A antigen expression by hepatocellular carcinoma cells. | lld:pubmed |
| pubmed-article:19428110 | pubmed:affiliation | The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Department of Genetics and Developmental Biology, Southeast University Medical School, Nanjing, Jiangsu 210009, China. | lld:pubmed |
| pubmed-article:19428110 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19428110 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19428110 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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