Linked Life Data

19427534

Source:http://linkedlifedata.com/resource/pubmed/id/19427534

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-5-11
pubmed:abstractText
Electrical impedance tomography (EIT) is a recently developed medical imaging method which has the potential to produce images of fast neuronal depolarization in the brain. The principle is that current remains in the extracellular space at rest but passes into the intracellular space during depolarization through open ion channels. As current passes into the intracellular space across the capacitance of cell membranes at higher frequencies, applied current needs to be below 100 Hz. A method is presented for its measurement with subtraction of the contemporaneous evoked potentials which occur in the same frequency band. Neuronal activity is evoked by stimulation and resistance is recorded from the potentials resulting from injection of a constant current square wave at 1 Hz with amplitude less than 25% of the threshold for stimulating neuronal activity. Potentials due to the evoked activity and the injected square wave are removed by subtraction. The method was validated with compound action potentials in crab walking leg nerve. Resistance changes of -0.85+/-0.4% (mean+/-SD) occurred which decreased from -0.97+/-0.43% to -0.46+/-0.16% with spacing of impedance current application electrodes from 2 to 8 mm but did not vary significantly with applied currents of 1-10 microA. These tallied with biophysical modelling, and so were consistent with a genuine physiological origin. This method appears to provide a reproducible and artefact free means for recording resistance changes during neuronal activity which could lead to the long-term goal of imaging of fast neural activity in the brain.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-10719998, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-11162269, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-11301240, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-1453778, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-14562737, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-14568449, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-1563224, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-15961042, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-16636407, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-16636408, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-16636411, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-16677955, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-17260380, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-17806271, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-18139009, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-18272402, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-19426819, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-19491442, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-19873125, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-2627768, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-2826937, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-3240638, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-3240651, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-3568577, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-4017442, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-5709872, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-5724946, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-680754, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-8528130, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-8606768, http://linkedlifedata.com/resource/pubmed/commentcorrection/19427534-9092607
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1872-678X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
30
pubmed:volume
180
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-96
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed-meshheading:19427534-Action Potentials, pubmed-meshheading:19427534-Animals, pubmed-meshheading:19427534-Artifacts, pubmed-meshheading:19427534-Brachyura, pubmed-meshheading:19427534-Brain, pubmed-meshheading:19427534-Cell Membrane, pubmed-meshheading:19427534-Electric Impedance, pubmed-meshheading:19427534-Electric Stimulation, pubmed-meshheading:19427534-Electronics, Medical, pubmed-meshheading:19427534-Electrophysiology, pubmed-meshheading:19427534-Extracellular Space, pubmed-meshheading:19427534-Humans, pubmed-meshheading:19427534-Ion Channels, pubmed-meshheading:19427534-Membrane Potentials, pubmed-meshheading:19427534-Neural Conduction, pubmed-meshheading:19427534-Neurons, pubmed-meshheading:19427534-Neurophysiology, pubmed-meshheading:19427534-Peripheral Nerves, pubmed-meshheading:19427534-Time Factors, pubmed-meshheading:19427534-Tomography
pubmed:year
2009
pubmed:articleTitle
A method for recording resistance changes non-invasively during neuronal depolarization with a view to imaging brain activity with electrical impedance tomography.
pubmed:affiliation
Department of Clinical Neurophysiology, University College London, London, UK. o.gilad@ucl.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural