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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
2009-7-28
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pubmed:abstractText |
Although the Hedgehog (Hh) pathway regulates development and progression of several types of cancer, its involvement in colon cancer remains unclear. We aimed to clarify the roles of Hh signaling in intestinal tumorigenesis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
|
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pubmed:issn |
1528-0012
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
629-38
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pubmed:meshHeading |
pubmed-meshheading:19427313-Adenomatous Polyposis Coli,
pubmed-meshheading:19427313-Animals,
pubmed-meshheading:19427313-Colonic Neoplasms,
pubmed-meshheading:19427313-Disease Models, Animal,
pubmed-meshheading:19427313-Down-Regulation,
pubmed-meshheading:19427313-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19427313-Genetic Predisposition to Disease,
pubmed-meshheading:19427313-Humans,
pubmed-meshheading:19427313-Immunohistochemistry,
pubmed-meshheading:19427313-In Situ Hybridization,
pubmed-meshheading:19427313-Mice,
pubmed-meshheading:19427313-Random Allocation,
pubmed-meshheading:19427313-Receptors, G-Protein-Coupled,
pubmed-meshheading:19427313-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19427313-Signal Transduction,
pubmed-meshheading:19427313-Transcription Factors,
pubmed-meshheading:19427313-Transfection,
pubmed-meshheading:19427313-Wnt Proteins,
pubmed-meshheading:19427313-beta Catenin
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pubmed:year |
2009
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|
pubmed:articleTitle |
Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.
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pubmed:affiliation |
Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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