Linked Life Data

19426138

Source:http://linkedlifedata.com/resource/pubmed/id/19426138

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-6-30
pubmed:abstractText
Polysialic acid (polySia) is a major regulator of cell-cell interactions in the developing nervous system and a key factor in maintaining neural plasticity. As a polyanionic molecule with high water binding capacity, polySia increases the intercellular space and creates conditions that are permissive for cellular plasticity. While the prevailing model highlights polySia as a non-specific regulator of cell-cell contacts, this review concentrates on recent studies in knockout mice indicating that a crucial function of polySia resides in controlling interactions mediated by its predominant protein carrier, the neural cell adhesion molecule NCAM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1431-6730
pubmed:author
pubmed:issnType
Print
pubmed:volume
390
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
567-74
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Brain development needs sugar: the role of polysialic acid in controlling NCAM functions.
pubmed:affiliation
Institute of Cellular Chemistry, OE 4330, Hannover Medical School, D-30625 Hannover, Germany. muehlenhoff.martina@mh-hannover.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't