Source:http://linkedlifedata.com/resource/pubmed/id/19425290
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2009-5-11
|
| pubmed:abstractText |
In addition to well-documented mood-stabilizing effects, lithium can be used in the treatment of acute brain injuries (ischemia) and chronic (neurodegenerative) diseases. Recent in vitro and in vivo studies reveal that the long-term treatment with lithium up-regulates cell survival molecules (Bcl-2, cAMP-responsive element binding protein, GRP 78, brain-derived neurotrophic factor, Hsp70) and down-regulates pro-apoptotic activities (e.g., excitotoxicity, p53, Bax, caspase, cytochrome C release, beta-amyloid peptide production and tau hyperphosphorylation) thus preventing or even reversing the neuronal cell death and neurogenesis retardation.
|
| pubmed:language |
rus
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1997-7298
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
Suppl 22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
49-55
|
| pubmed:meshHeading |
pubmed-meshheading:19425290-Antidepressive Agents,
pubmed-meshheading:19425290-Antimanic Agents,
pubmed-meshheading:19425290-Apoptosis,
pubmed-meshheading:19425290-Brain Ischemia,
pubmed-meshheading:19425290-Humans,
pubmed-meshheading:19425290-Lithium Compounds,
pubmed-meshheading:19425290-Neurogenesis,
pubmed-meshheading:19425290-Neurons,
pubmed-meshheading:19425290-Proteins
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| pubmed:year |
2008
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| pubmed:articleTitle |
[Neurobiology of lithium].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|