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pubmed:abstractText |
Transcranial magnetic stimulation (TMS) is a relatively noninvasive brain stimulation technology that can focally stimulate the human cortex. One significant limitation of much of the TMS research to date concerns the nature of the placebo or sham conditions used. When TMS pulses are delivered repetitively (especially prefrontal TMS), it is often experienced as painful. Most sham TMS techniques produce identical sounds to active TMS, but they do not cause much, if any, scalp or facial sensation or discomfort. This is a serious problem when investigators are attempting to evaluate the effects of TMS by using traditional sham techniques because of unintended systematic differences between real and sham TMS groups (ie, confounds). As long as traditional approaches to sham TMS are used, the validity of the inferences regarding the efficacy of TMS will be limited. Although some other sophisticated systems have been developed to address these concerns, they tend to be expensive and lack portability. Portability will likely become more and more important as TMS applications expand into different clinical areas (eg, TMS in the postanesthesia care unit after surgery).
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