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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-5-21
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pubmed:abstractText |
Sphingosine-1-phosphate (S1P) is a potent bioactive phospholipid responsible for a variety of vascular cell responses. Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator of genes essential for adaptation to low oxygen. S1P and HIF-1 are both important mediators of vascular cell responses such as migation, proliferation, and survival. Studies have shown that nonhypoxic stimuli can activate HIF-1 in oxygenated conditions. Here, we attempt to determine whether S1P can modulate the vascular activation of HIF-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hif1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hif1a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lysosphingolipid,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/sphingosine 1-phosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
902-8
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pubmed:meshHeading |
pubmed-meshheading:19423865-Animals,
pubmed-meshheading:19423865-Cattle,
pubmed-meshheading:19423865-Cell Hypoxia,
pubmed-meshheading:19423865-Cell Nucleus,
pubmed-meshheading:19423865-Cells, Cultured,
pubmed-meshheading:19423865-Endothelial Cells,
pubmed-meshheading:19423865-Gene Expression Regulation,
pubmed-meshheading:19423865-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:19423865-Lysophospholipids,
pubmed-meshheading:19423865-Mice,
pubmed-meshheading:19423865-Muscle, Smooth, Vascular,
pubmed-meshheading:19423865-Myocytes, Smooth Muscle,
pubmed-meshheading:19423865-Protein Stability,
pubmed-meshheading:19423865-RNA, Small Interfering,
pubmed-meshheading:19423865-RNA Interference,
pubmed-meshheading:19423865-Rats,
pubmed-meshheading:19423865-Rats, Wistar,
pubmed-meshheading:19423865-Receptors, Lysosphingolipid,
pubmed-meshheading:19423865-Sphingosine,
pubmed-meshheading:19423865-Time Factors,
pubmed-meshheading:19423865-Transcription, Genetic,
pubmed-meshheading:19423865-Transfection
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pubmed:year |
2009
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pubmed:articleTitle |
Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells.
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pubmed:affiliation |
Centre de Recherche du CHUQ, L'Hôtel-Dieu de Québec, Québec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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