19423348

Source:http://linkedlifedata.com/resource/pubmed/id/19423348

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0065631, umls-concept:C0076271, umls-concept:C0205349, umls-concept:C0215848, umls-concept:C0243071, umls-concept:C0449830, umls-concept:C0936012, umls-concept:C1822686, umls-concept:C2348110, umls-concept:C2348977, umls-concept:C2827597
pubmed:issue	14
pubmed:dateCreated	2009-7-13
pubmed:abstractText	We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA40355, http://linkedlifedata.com/resource/pubmed/grant/P01 CA042745-22, http://linkedlifedata.com/resource/pubmed/grant/P01 CA42745, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-24, http://linkedlifedata.com/resource/pubmed/grant/R01 GM061870-09, http://linkedlifedata.com/resource/pubmed/grant/R01GM61870-09
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Furans, http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, http://linkedlifedata.com/resource/pubmed/chemical/Lignans, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A, http://linkedlifedata.com/resource/pubmed/chemical/manassantin A, http://linkedlifedata.com/resource/pubmed/chemical/tetrahydrofuran
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1464-3405
pubmed:author	pubmed-author:DewhirstMark WMW, pubmed-author:HongJiyongJ, pubmed-author:HuXiangqianX, pubmed-author:KasperAmanda CAC, pubmed-author:KimHyoungsuH, pubmed-author:MoonEui JungEJ, pubmed-author:ParkYonghoY, pubmed-author:WootenCeshea MCM, pubmed-author:YangWeitaoW
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	19
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3783-6
pubmed:dateRevised	2010-12-3
pubmed:meshHeading	pubmed-meshheading:19423348-Animals, pubmed-meshheading:19423348-Cell Line, pubmed-meshheading:19423348-Furans, pubmed-meshheading:19423348-Hypoxia-Inducible Factor 1, pubmed-meshheading:19423348-Lignans, pubmed-meshheading:19423348-Mice, pubmed-meshheading:19423348-Vascular Endothelial Growth Factor A
pubmed:year	2009
pubmed:articleTitle	Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.
pubmed:affiliation	Department of Chemistry, Duke University, Durham, NC 27708, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural