Linked Life Data

19422813

Source:http://linkedlifedata.com/resource/pubmed/id/19422813

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-6-22
pubmed:abstractText
Organochlorine pesticides (OCs) have been associated with breast cancer development and progression. However, the deleterious mechanisms exerted by these contaminants are yet unclear and need to be further elucidated. In the present study, we investigated the effects of a number of OCs (previously detected in human serum from a Spanish population), individually or in combination, on normal human mammary epithelial cells (HMEC) at concentrations close to those found in human beings. The results obtained after a 96-h exposure indicated that OCs exert a clear cytotoxic effect on these cells at higher concentrations than those found in human beings. DDT-derivative organochlorines (DDT and its metabolites, DDE and DDD) are individually more cytotoxic than non-DDT-derivative organochlorines (aldrin and dieldrin). On the contrary, combinations of non-DDT organochlorines were clearly more cytotoxic than combinations of DDT-derivative organochlorines at concentrations close to those described in human serum. Additionally, transcriptional regulation arrays showed that the exposure of HMEC to an environmentally relevant mixture of OCs (p,p'-DDD plus p,p'-DDE plus o,p'-DDE plus aldrin plus dieldrin) sharply upregulated the expression of a number of protein kinases genes, such as ACVRL1, ALK-1, KIT, ERBB3, and ALK-1 at concentrations close to those detected in human populations. Taken together, these findings show a detrimental effect of OCs on human breast cells and indicate a possible association between exposure to organochlorine pesticide combinations and the induction of transformation processes in human breast cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1872-7786
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
180
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
485-91
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Differential effects exerted on human mammary epithelial cells by environmentally relevant organochlorine pesticides either individually or in combination.
pubmed:affiliation
Research Group in Environment and Health, Unit of Toxicology, Health Sciences Center, University of Las Palmas de Gran Canaria and Instituto Canario de Investigación del Cáncer, Las Palmas de Gran Canaria, Spain. jfernandez@dbbf.ulpgc.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't