19422391

Source:http://linkedlifedata.com/resource/pubmed/id/19422391

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001521, umls-concept:C0002921, umls-concept:C0002934, umls-concept:C0033200, umls-concept:C0034830, umls-concept:C0441712, umls-concept:C1521991
pubmed:issue	5
pubmed:dateCreated	2009-7-14
pubmed:abstractText	Many local anaesthetics are non-competitive inhibitors of nicotinic receptors (acetylcholine receptor, AChR). Proadifen induces a high-affinity state of the receptor, but its mechanism of action and that of an analogue, adiphenine, is unknown.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/GM045095, http://linkedlifedata.com/resource/pubmed/grant/R01 NS045095-04
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7502536
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine, http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local, http://linkedlifedata.com/resource/pubmed/chemical/Chrnb1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Chrne protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Diphenylacetic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Proadifen, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nicotinic, http://linkedlifedata.com/resource/pubmed/chemical/adiphenine
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1476-5381
pubmed:author	pubmed-author:BouzatCeciliaC, pubmed-author:DilgerJames PJP, pubmed-author:GumilarFernandaF, pubmed-author:SpitzmaulGuillermoG
pubmed:issnType	Electronic
pubmed:volume	157
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	804-17
pubmed:dateRevised	2010-9-27
pubmed:meshHeading	pubmed-meshheading:19422391-Acetylcholine, pubmed-meshheading:19422391-Anesthetics, Local, pubmed-meshheading:19422391-Animals, pubmed-meshheading:19422391-Binding Sites, pubmed-meshheading:19422391-Cell Line, pubmed-meshheading:19422391-Diphenylacetic Acids, pubmed-meshheading:19422391-Dose-Response Relationship, Drug, pubmed-meshheading:19422391-Humans, pubmed-meshheading:19422391-Ion Channel Gating, pubmed-meshheading:19422391-Kinetics, pubmed-meshheading:19422391-Membrane Potentials, pubmed-meshheading:19422391-Mice, pubmed-meshheading:19422391-Nicotinic Antagonists, pubmed-meshheading:19422391-Proadifen, pubmed-meshheading:19422391-Protein Conformation, pubmed-meshheading:19422391-Receptors, Nicotinic, pubmed-meshheading:19422391-Transfection
pubmed:year	2009
pubmed:articleTitle	The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.
pubmed:affiliation	Instituto de Investigaciones Bioquímicas, Universidad Nacional del Sur-CONICET, Bahía Blanca, Argentina.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural