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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-5-7
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pubmed:abstractText |
CHI3LI encoding the inflammatory glycoprotein YKL-40 is located on chromosome 1q32.1. YKL-40 is involved in inflammatory processes and patients with Type 2 Diabetes (T2D) have elevated circulating YKL-40 levels which correlate with their level of insulin resistance. Interestingly, it has been reported that rs10399931 (-329 G/A) of CHI3LI contributes to the inter-individual plasma YKL-40 levels in patients with sarcoidosis, and that rs4950928 (-131 C/G) is a susceptibility polymorphism for asthma and a decline in lung function. We hypothesized that single nucleotide polymorphisms (SNPs) or haplotypes thereof the CHI3LI locus might influence risk of T2D. The aim of the present study was to investigate the putative association between SNPs and haplotype blocks of CHI3LI and T2D and T2D related quantitative traits.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e5469
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19421404-Adipokines,
pubmed-meshheading:19421404-Adult,
pubmed-meshheading:19421404-Case-Control Studies,
pubmed-meshheading:19421404-Cohort Studies,
pubmed-meshheading:19421404-Diabetes Mellitus, Type 2,
pubmed-meshheading:19421404-Female,
pubmed-meshheading:19421404-Genetic Predisposition to Disease,
pubmed-meshheading:19421404-Genotype,
pubmed-meshheading:19421404-Glucose Tolerance Test,
pubmed-meshheading:19421404-Glycoproteins,
pubmed-meshheading:19421404-Haplotypes,
pubmed-meshheading:19421404-Humans,
pubmed-meshheading:19421404-Insulin Resistance,
pubmed-meshheading:19421404-Lectins,
pubmed-meshheading:19421404-Male,
pubmed-meshheading:19421404-Microsatellite Repeats,
pubmed-meshheading:19421404-Middle Aged,
pubmed-meshheading:19421404-Phenotype,
pubmed-meshheading:19421404-Polymorphism, Single Nucleotide,
pubmed-meshheading:19421404-Quantitative Trait Loci,
pubmed-meshheading:19421404-Risk Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits.
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pubmed:affiliation |
Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark. cnr@dadlnet.dk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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