Linked Life Data

19420895

Source:http://linkedlifedata.com/resource/pubmed/id/19420895

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-5-7
pubmed:abstractText
Polypharmacy, the use of multiple medications, is commonly prescribed in the elderly but leads to reduced compliance with drug treatment regimens and increased risk of adverse drug reactions. This study was performed to systematically review the results of previous studies to assess the effects of interventions to improve prescription quality on reduction of the number of medications in elderly patients with polypharmacy, and to determine the most effective types of intervention in such cases. Relevant articles in the English language literature were retrieved by keyword searches on MEDLINE, the Cochrane Library, and cited references. The criteria for inclusion in this review were as follows: 1) studies in elderly subjects taking multiple medications or frail elderly subjects assumed to be taking multiple medications; 2) study interventions were intended to improve quality of drug use; 3) changes in the number of medications prescribed during the intervention period were reported; 4) the study designs were controlled clinical studies. Twenty-seven articles, including 28 controlled studies, matched all the inclusion criteria. The interventions in the studies included in the review were categorized into two groups: a medication review by medical professionals (26 studies); and a request to prescribing physicians for re-evaluation of the drug use for their patients (2 studies). Medication reviews by medical professionals, mainly pharmacists, resulted in a significant reduction of prescribed drugs (median, 0.45 drugs; 95%CI, 0.11-0.76). The differences in effects among intervention methods could not be investigated because of a lack of diversity in the methods used.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-6903
pubmed:author
pubmed:issnType
Print
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
631-45
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Systematic review of the effects of improvement of prescription to reduce the number of medications in the elderly with polypharmacy.
pubmed:affiliation
Osaka Medical Center for Health Science and Promotion, Osaka, Japan. maeda@kenkoukagaku.jp
pubmed:publicationType
Journal Article, Meta-Analysis