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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-9-24
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pubmed:abstractText |
Mammalian programmed cell death (PD)-1 is a membrane-associated receptor regulating the balance between T-cell activation, tolerance, and immunopathology; however, its role in neurons has not yet been defined. The hypothesis that PD-1 signaling actively promotes retinal ganglion cell (RGC) death within the developing mouse retina was investigated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cd274 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pdcd1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pdcd1lg2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Ligand 2...,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1552-5783
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pubmed:author |
pubmed-author:BraunJonathanJ,
pubmed-author:ChanAnn MAM,
pubmed-author:ChenLingL,
pubmed-author:FranciscoLoise MLM,
pubmed-author:FreemanGordon JGJ,
pubmed-author:GordonLynn KLK,
pubmed-author:MareninovSergeyS,
pubmed-author:ShamCaroline WCW,
pubmed-author:SharpeArlene HAH,
pubmed-author:WuYinY,
pubmed-author:YangXian-JieXJ
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4941-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19420345-Animals,
pubmed-meshheading:19420345-Animals, Newborn,
pubmed-meshheading:19420345-Antigens, CD274,
pubmed-meshheading:19420345-Antigens, CD80,
pubmed-meshheading:19420345-Antigens, Surface,
pubmed-meshheading:19420345-Apoptosis,
pubmed-meshheading:19420345-Apoptosis Regulatory Proteins,
pubmed-meshheading:19420345-Blotting, Western,
pubmed-meshheading:19420345-Cell Count,
pubmed-meshheading:19420345-Cell Survival,
pubmed-meshheading:19420345-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:19420345-Gene Expression Regulation, Developmental,
pubmed-meshheading:19420345-Ligands,
pubmed-meshheading:19420345-Lymphocyte Activation,
pubmed-meshheading:19420345-Membrane Glycoproteins,
pubmed-meshheading:19420345-Mice,
pubmed-meshheading:19420345-Mice, Inbred C57BL,
pubmed-meshheading:19420345-Mice, Knockout,
pubmed-meshheading:19420345-Peptides,
pubmed-meshheading:19420345-Programmed Cell Death 1 Ligand 2 Protein,
pubmed-meshheading:19420345-Programmed Cell Death 1 Receptor,
pubmed-meshheading:19420345-RNA, Messenger,
pubmed-meshheading:19420345-Retina,
pubmed-meshheading:19420345-Retinal Ganglion Cells,
pubmed-meshheading:19420345-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19420345-Signal Transduction
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pubmed:year |
2009
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pubmed:articleTitle |
Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells.
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pubmed:affiliation |
Department of Molecular and Medical Pharmacology, Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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