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pubmed-article:1942009pubmed:abstractTextThe molecular diversity of SIVsmm/PBj proviral genomes in tissues of an infected macaque was analyzed. Molecular clones derived directly from intestinal tissue DNA were heterogenous, and contained LTRs with one or two NF-kB binding sites. LTRs with one NF-kB site predominated (approximately 75%). Virions derived from biologically active chimeric DNA clones with one or two NF-kB sites did not induce the acute death syndrome characteristic of PBj infection. These results suggest that either the duplicated NF-kB site acts in concert with other important viral determinants, or plays no role in producing the PBj syndrome.lld:pubmed
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pubmed-article:1942009pubmed:articleTitleMolecular diversity of SIVsmm/PBj and a cognate variant, SIVsmm/PGg.lld:pubmed
pubmed-article:1942009pubmed:affiliationDepartment of Microbiology, Georgetown University, Rockville, MD.lld:pubmed
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pubmed-article:1942009pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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