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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-12-13
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pubmed:abstractText |
The molecular diversity of SIVsmm/PBj proviral genomes in tissues of an infected macaque was analyzed. Molecular clones derived directly from intestinal tissue DNA were heterogenous, and contained LTRs with one or two NF-kB binding sites. LTRs with one NF-kB site predominated (approximately 75%). Virions derived from biologically active chimeric DNA clones with one or two NF-kB sites did not induce the acute death syndrome characteristic of PBj infection. These results suggest that either the duplicated NF-kB site acts in concert with other important viral determinants, or plays no role in producing the PBj syndrome.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0047-2565
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
188-92
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1942009-Amino Acid Sequence,
pubmed-meshheading:1942009-Animals,
pubmed-meshheading:1942009-Base Sequence,
pubmed-meshheading:1942009-Cell Line,
pubmed-meshheading:1942009-Cloning, Molecular,
pubmed-meshheading:1942009-DNA, Viral,
pubmed-meshheading:1942009-Genetic Variation,
pubmed-meshheading:1942009-HIV Enhancer,
pubmed-meshheading:1942009-HIV Envelope Protein gp120,
pubmed-meshheading:1942009-Humans,
pubmed-meshheading:1942009-Macaca nemestrina,
pubmed-meshheading:1942009-Membrane Glycoproteins,
pubmed-meshheading:1942009-Molecular Sequence Data,
pubmed-meshheading:1942009-Peyer's Patches,
pubmed-meshheading:1942009-Polymerase Chain Reaction,
pubmed-meshheading:1942009-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1942009-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:1942009-Simian immunodeficiency virus,
pubmed-meshheading:1942009-Spleen,
pubmed-meshheading:1942009-Viral Envelope Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
Molecular diversity of SIVsmm/PBj and a cognate variant, SIVsmm/PGg.
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pubmed:affiliation |
Department of Microbiology, Georgetown University, Rockville, MD.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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