|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
2009-7-2
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|
pubmed:abstractText |
3'-Deoxy-4'-azaribonucleosides (15a-d) were synthesized starting from the commercially available (4R)-trans-4-hydroxy-l-proline 7. From biological evaluations, 15b and 15d emerged as potent inhibitors of HCV replication on a replicon assay. These findings demonstrate that synthesized pyrrolidine nucleosides represent a new template for antiviral or other biological studies and could be considered for novel combination therapy against HCV infection using nucleoside inhibitors and non-nucleoside inhibitors of HCV NS5B.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1520-4804
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
9
|
|
pubmed:volume |
52
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4054-7
|
|
pubmed:meshHeading |
pubmed-meshheading:19419173-Antiviral Agents,
pubmed-meshheading:19419173-Deoxyribonucleosides,
pubmed-meshheading:19419173-Hepacivirus,
pubmed-meshheading:19419173-Humans,
pubmed-meshheading:19419173-Proline,
pubmed-meshheading:19419173-Pyrrolidines,
pubmed-meshheading:19419173-RNA, Viral,
pubmed-meshheading:19419173-Stereoisomerism,
pubmed-meshheading:19419173-Viral Nonstructural Proteins,
pubmed-meshheading:19419173-Virus Replication
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Stereoselective synthesis and biological evaluations of novel 3'-deoxy-4'-azaribonucleosides as inhibitors of hepatitis C virus RNA replication.
|
|
pubmed:affiliation |
Dipartimento di Scienze Chimiche, Universita di Catania, Catania 95125, Italy. uchiacchio@unict.it.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
