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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-5-26
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pubmed:abstractText |
Oxycodone is a mu-opioid receptor agonist that is metabolized mainly in the liver by cytochrome P450 3A and 2D6 enzymes. Rifampin is a strong inducer of several drug-metabolizing enzymes. The authors studied the interaction of rifampin with oxycodone. Their hypothesis was that rifampin enhances the CYP3A-mediated metabolism of oxycodone and attenuates its pharmacologic effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1528-1175
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1371-8
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pubmed:meshHeading |
pubmed-meshheading:19417618-Administration, Oral,
pubmed-meshheading:19417618-Adult,
pubmed-meshheading:19417618-Analgesics, Opioid,
pubmed-meshheading:19417618-Anti-Bacterial Agents,
pubmed-meshheading:19417618-Biological Availability,
pubmed-meshheading:19417618-Cross-Over Studies,
pubmed-meshheading:19417618-Cytochrome P-450 CYP3A,
pubmed-meshheading:19417618-Double-Blind Method,
pubmed-meshheading:19417618-Drug Interactions,
pubmed-meshheading:19417618-Enzyme Induction,
pubmed-meshheading:19417618-Female,
pubmed-meshheading:19417618-Half-Life,
pubmed-meshheading:19417618-Humans,
pubmed-meshheading:19417618-Injections, Intravenous,
pubmed-meshheading:19417618-Male,
pubmed-meshheading:19417618-Oxycodone,
pubmed-meshheading:19417618-Rifampin,
pubmed-meshheading:19417618-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Rifampin greatly reduces the plasma concentrations of intravenous and oral oxycodone.
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pubmed:affiliation |
Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, Turku, Finland. tuija.nieminen@utu.fi
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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