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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-7-9
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pubmed:abstractText |
Vitiligo is a common depigmenting disorder resulting from the loss of functional melanocytes in the skin. It is hypothesized to be of autoimmune origin. Mannan-binding lectin (MBL) plays an important role in innate immunity. It helps in the clearance of apoptotic cells and in complement activation. Genetic variability due to structural and promoter polymorphisms in the MBL2 gene has been reported to be associated with increased risk for several autoimmune diseases including vitiligo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1365-2133
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
161
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-9
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pubmed:meshHeading |
pubmed-meshheading:19416237-Adult,
pubmed-meshheading:19416237-Case-Control Studies,
pubmed-meshheading:19416237-Codon,
pubmed-meshheading:19416237-Exons,
pubmed-meshheading:19416237-Female,
pubmed-meshheading:19416237-Genetic Predisposition to Disease,
pubmed-meshheading:19416237-Genotype,
pubmed-meshheading:19416237-Heteroduplex Analysis,
pubmed-meshheading:19416237-Humans,
pubmed-meshheading:19416237-Male,
pubmed-meshheading:19416237-Mannose-Binding Lectin,
pubmed-meshheading:19416237-Polymerase Chain Reaction,
pubmed-meshheading:19416237-Polymorphism, Genetic,
pubmed-meshheading:19416237-Promoter Regions, Genetic,
pubmed-meshheading:19416237-Vitiligo
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pubmed:year |
2009
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pubmed:articleTitle |
Lack of genetic association of promoter and structural variants of mannan-binding lectin (MBL2) gene with susceptibility to generalized vitiligo.
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pubmed:affiliation |
Department of Biochemistry, The Maharaja Sayajirao University of Baroda, Vadodara-390002, Gujarat, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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