Linked Life Data

19416211

Source:http://linkedlifedata.com/resource/pubmed/id/19416211

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-5-6
pubmed:abstractText
Rxfp2 is present in putative mesangial cells at embryonic stage 18 (E18) in the rat kidney, suggesting that insulin-like peptide 3 is involved in glomerulogenesis. One of the main regulatory factors in glomerulogenesis is the basic helix-loop-helix transcription factor Pod1. Therefore, we examined the expression of Rxfp2 relative to Pod1 in the fetal and neonatal mouse kidney and tested the hypothesis that Rxfp2 is a downstream target of Pod1. Rxfp2 gene expression in the neonatal kidney was highest at E14 and E16 but decreased significantly at E18. This was not correlated with increased Pod1 expression. However, there was a significant increase in Rxfp2 expression in the kidneys of Pod1(-/-) mice at E18. These data suggest that Pod1 may negatively regulate Rxfp2 expression in the developing glomerulus to promote cell proliferation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
317-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Regulation of Rxfp2 (Lgr8) expression in the mouse fetal kidney by the transcription factor Pod1 (Tcf 21).
pubmed:affiliation
Department of Zoology, University of Melbourne, Parkville, Victoria, Australia. m.familari@unimelb.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't