Linked Life Data

19416157

Source:http://linkedlifedata.com/resource/pubmed/id/19416157

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-5-6
pubmed:abstractText
Functions of the relaxin peptide family have been primarily investigated in mammals, and little attention has been paid to nonmammalian species. In this work, we performed phylogenetic and syntenic data analyses to identify the number and orthologous and paralogous relationships of relaxin family genes in teleosts and humans. Additionally, we performed reverse transcription PCR to determine the expression of three members of the relaxin family in zebrafish brain and gonads. We found evidence that teleosts harbor orthologs of the human INSL5, H2, H3, and INSL3 genes, so-named RLND/RLNE, RLNC, RLN3a/RLN3b, and RLNF in teleosts, respectively. Moreover, the presence of mRNA for RLN3a, RLND, and RLNF in both male and female brain and gonads of zebrafish suggests that all three genes are expressed in these tissues of this teleost. Differential expression and/or regulation of these genes will be explored in future experimental work.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-4
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Relaxin family genes in humans and teleosts.
pubmed:affiliation
Department of Biology, Acadia University, Wolfville, Nova Scotia, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't