Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-6-30
pubmed:abstractText
Tbx18 is a T-Box transcription factor that has specific expression and indispensible function in the lower urinary tract. Here, we report the generation and characterization of a bacterial artificial chromosome (BAC) transgene expressing Cre under the control of Tbx18 regulatory elements. When crossed to the ROSA26R-lacZ reporter mice, the Tbx18-Cre transgene mediates loxP recombination in the mesenchymal derivatives in the lower urinary tract, especially in the smooth muscle cells (SMCs) and the stromal cells. There is no expression of this transgene in the urothelium or in the kidney. This Tbx18-Cre transgene recapitulates the endogenous Tbx18 expression in the urinary system and can be used for the study of the development, physiology, and diseases in the urinary tract. Its additional expression in the epicardium, limb, vibrissae, and other structures would be useful for studies in the relevant fields.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-11668676, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-12399320, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-15057312, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-15257458, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-15381752, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-15930111, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-16511601, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-16641094, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-16688725, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-16822174, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-17172448, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-17442697, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-17657166, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-17881488, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-18480752, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-9771703, http://linkedlifedata.com/resource/pubmed/commentcorrection/19415630-9916792
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1526-968X
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-13
pubmed:dateRevised
2011-6-7
pubmed:meshHeading
pubmed-meshheading:19415630-Animals, pubmed-meshheading:19415630-Binding Sites, pubmed-meshheading:19415630-Embryo, Mammalian, pubmed-meshheading:19415630-Female, pubmed-meshheading:19415630-Gene Expression Regulation, Developmental, pubmed-meshheading:19415630-Genetic Techniques, pubmed-meshheading:19415630-Integrases, pubmed-meshheading:19415630-Kidney, pubmed-meshheading:19415630-Lac Operon, pubmed-meshheading:19415630-Male, pubmed-meshheading:19415630-Mice, pubmed-meshheading:19415630-Mice, Inbred C57BL, pubmed-meshheading:19415630-Mice, Inbred CBA, pubmed-meshheading:19415630-Mice, Transgenic, pubmed-meshheading:19415630-Polymerase Chain Reaction, pubmed-meshheading:19415630-Recombination, Genetic, pubmed-meshheading:19415630-T-Box Domain Proteins, pubmed-meshheading:19415630-Time Factors, pubmed-meshheading:19415630-Transgenes, pubmed-meshheading:19415630-Urinary Tract, pubmed-meshheading:19415630-Urothelium
pubmed:year
2009
pubmed:articleTitle
Cre/lox recombination in the lower urinary tract.
pubmed:affiliation
Department of Internal Medicine, Renal Division, Washington University School of Medicine, St. Louis, MO 63110, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural