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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-6-25
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pubmed:abstractText |
Clarithromycin decreases CYP3A4 activity and thus gradually inhibits its own metabolism as well as that of coadministered drugs. The aim of this study was to obtain an understanding of the time course of these changes. The plasma concentration-time profiles of clarithromycin and its active metabolite, 14(R)-hydroxy-clarithromycin, in 12 young healthy volunteers after oral administration of a clarithromycin suspension (500 mg twice a day [b.i.d.] for seven doses) were modeled by population pharmacokinetic analysis in the NONMEM program. The nonlinearity of clarithromycin metabolism was considered during model development, and the metabolite disposition kinetics were assumed to be linear. The absorption kinetics of clarithromycin were best described by a Weibull function model. The pharmacokinetics of clarithromycin and its 14(R)-hydroxyl metabolite were adequately described by a one-compartment model each for clarithromycin and its metabolite as well as an inhibition compartment that reflects the autoinhibition of clarithromycin metabolism. Up to 90% of the apparent total clarithromycin clearance (60 liters/h) was susceptible to reversible autoinhibition, depending on the concentration in the inhibition compartment. The proposed semimechanistic population pharmacokinetic model successfully described the autoinhibition of clarithromycin metabolism and may be used to adjust the doses of other drugs that are metabolized by CYP3A4 and that are coadministered with clarithromycin. Simulations showed that for the standard dose of 500 mg b.i.d., no further increase in the level of exposure occurs after approximately 48 h of treatment. For a 1,000-mg b.i.d. dose, the achievement of steady state is expected to take several days and to achieve a 3.6-fold higher level of clarithromycin exposure than the 500-mg b.i.d. dose. This evaluation provides a rationale for safer and more effective therapy with clarithromycin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19414584-10589373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19414584-10950845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19414584-11328768,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19414584-9728893
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1098-6596
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2892-901
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19414584-Administration, Oral,
pubmed-meshheading:19414584-Adult,
pubmed-meshheading:19414584-Anti-Bacterial Agents,
pubmed-meshheading:19414584-Clarithromycin,
pubmed-meshheading:19414584-Computer Simulation,
pubmed-meshheading:19414584-Female,
pubmed-meshheading:19414584-Humans,
pubmed-meshheading:19414584-Male,
pubmed-meshheading:19414584-Models, Theoretical,
pubmed-meshheading:19414584-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Modeling the autoinhibition of clarithromycin metabolism during repeated oral administration.
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pubmed:affiliation |
Department of Pharmacology, Clinical Pharmacology, University Hospital, University of Cologne, Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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