Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1991-12-17
|
| pubmed:abstractText |
To explore the relationship between vitamin A deficiency and persistent diarrhea among young children, we studied the vitamin A status of 23 children greater than 5 years of age with persistent diarrhea by performing conjunctival impression cytology (CIC) and the relative dose-response test (RDR) as a measure of liver reserve of vitamin A. The control group consisted of 23 age- and sex-matched children who were otherwise healthy in whom CIC was performed and fasting plasma retinol values were determined. The criteria for vitamin A deficiency in CIC were paucity of goblet cells and scanty, abnormal epithelial cells. None of these children had ocular manifestations of vitamin A deficiency. Among the children with persistent diarrhea, CIC characteristic of vitamin A deficiency was found in 17 (group 1) and CIC results were normal in six (group 2). In group 1, the serum retinol levels were 1 +/- 1 microgram/dl, and RDR was 88 +/- 14. In group 2, the serum retinol levels were 8 +/- 4 micrograms/dl (p less than 0.001) and the RDR was 16 +/- 12 (p less than 0.001). In the control group, the CIC results were normal in all the children and the plasma retinol levels in these children were 19 +/- 8 micrograms/dl. In conclusion, 17 of 23 children with persistent diarrhea had abnormal CIC results, significantly low serum retinol levels, and significantly high RDR results, although they had not yet manifested xerophthalmia.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0277-2116
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
168-75
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1941410-Child, Preschool,
pubmed-meshheading:1941410-Chronic Disease,
pubmed-meshheading:1941410-Conjunctiva,
pubmed-meshheading:1941410-Diarrhea,
pubmed-meshheading:1941410-Dose-Response Relationship, Drug,
pubmed-meshheading:1941410-Female,
pubmed-meshheading:1941410-Humans,
pubmed-meshheading:1941410-Infant,
pubmed-meshheading:1941410-Male,
pubmed-meshheading:1941410-Nutritional Status,
pubmed-meshheading:1941410-Vitamin A,
pubmed-meshheading:1941410-Vitamin A Deficiency
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Assessment of preclinical vitamin A deficiency in children with persistent diarrhea.
|
| pubmed:affiliation |
Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
|
| pubmed:publicationType |
Journal Article
|