Linked Life Data

19412730

Source:http://linkedlifedata.com/resource/pubmed/id/19412730

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2009-12-3
pubmed:abstractText
Hepatic stellate cells (HSCs) play an important role in the development of hepatic fibrosis. Heat shock protein 90 (Hsp90) is essential for the maturation and activity of a varied group of proteins involved in signal transduction and cell cycle regulation. In this study, we found that two Hsp90 inhibitors, VER-49009 and its analog VER-49009M, inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells. Akt expression was decreased by the treatment of Hsp90 inhibitors in CFSC cells. Based on these findings, we propose that the inhibition of Hsp90 might be a rational approach in the prevention of liver fibrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1573-4919
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
330
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro.
pubmed:affiliation
Shanghai Institute of Materia Medica, Chinese Academy of Science, 201203, Shanghai, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't