Source:http://linkedlifedata.com/resource/pubmed/id/19409967
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2009-7-3
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| pubmed:abstractText |
A multicenter randomized clinical trial demonstrated that acute ischemic stroke patients treated with edaravone, a scavenger of hydroxyl radicals, had significant functional improvement. We tested the hypothesis that edaravone has protective effects against white matter lesions (WML) and endothelial injury, using a rat chronic hypoperfusion model. Adult Wistar rats underwent ligation of bilateral common carotid artery (LBCCA) and were divided into the edaravone group (injected once only immediately after LBCCA [n=39, ED(1)]; and injected on three consecutive days [n=39, ED(3)]), the vehicle group (n=39), and the sham group (n=15). Cerebral blood flow, Morris water maze performance, footprint test for locomotor function, immunohistochemical analyses and Western blot analysis were performed before and after LBCCA. The ED(3) group upregulated endothelial nitric oxide synthase and attenuated Evans Blue extravasation at day 3 after LBCCA (P<0.05). Edaravone markedly suppressed accumulation of 4-hydroxy-2-nonenal-modified protein and 8-hydroxy-deoxyguanosine (P<0.01), and loss of oligodendrocytes (P<0.05) in the cerebral white matter at days 3, 7, 14, 21 and 28 after LBCCA. These results were more evident in the ED(3) group. Moreover, at day 21 after LBCCA, spatial memory but not motor function, and axonal damage were significantly improved by three-time treatment of edaravone (P<0.05). Our results indicated that 3-day treatment with edaravone provides protection against WML through endothelial protection and free radical scavenging and suggested that edaravone is potentially useful for the treatment of cognitive impairment.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antipyrine,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/phenylmethylpyrazolone
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1873-7544
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
18
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| pubmed:volume |
162
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
317-27
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| pubmed:meshHeading |
pubmed-meshheading:19409967-Animals,
pubmed-meshheading:19409967-Antipyrine,
pubmed-meshheading:19409967-Apoptosis,
pubmed-meshheading:19409967-Axons,
pubmed-meshheading:19409967-Blood-Brain Barrier,
pubmed-meshheading:19409967-Brain,
pubmed-meshheading:19409967-Brain Ischemia,
pubmed-meshheading:19409967-Cell Proliferation,
pubmed-meshheading:19409967-Cerebrovascular Circulation,
pubmed-meshheading:19409967-Chronic Disease,
pubmed-meshheading:19409967-DNA Damage,
pubmed-meshheading:19409967-Endothelium, Vascular,
pubmed-meshheading:19409967-Free Radical Scavengers,
pubmed-meshheading:19409967-Lipid Peroxidation,
pubmed-meshheading:19409967-Male,
pubmed-meshheading:19409967-Maze Learning,
pubmed-meshheading:19409967-Memory,
pubmed-meshheading:19409967-Motor Activity,
pubmed-meshheading:19409967-Neuroprotective Agents,
pubmed-meshheading:19409967-Nitric Oxide Synthase Type III,
pubmed-meshheading:19409967-Oligodendroglia,
pubmed-meshheading:19409967-Oxidation-Reduction,
pubmed-meshheading:19409967-Rats,
pubmed-meshheading:19409967-Rats, Wistar
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| pubmed:year |
2009
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| pubmed:articleTitle |
Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model.
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| pubmed:affiliation |
Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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