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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-5-15
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pubmed:abstractText |
A series of novel cyanopyridyl based molecules (1-14) were designed, synthesized and probed for inhibition of mammalian target of rapamycin (mTOR) activity. Compound 14 was found to be a potent inhibitor of mTOR activity as assessed by enzyme-linked immunoassays and Western blot analysis. Most importantly, systemic application (intraperitoneal; ip) of compound 14 significantly suppressed macroscopic and histological abnormalities associated with chemically-induced murine colitis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BhatiaDimpleD,
pubmed-author:BhattPoojaP,
pubmed-author:BhondeMandar RMR,
pubmed-author:DadarkarShruta SSS,
pubmed-author:DagiaNilesh MNM,
pubmed-author:DeoreVijaykumarV,
pubmed-author:DesaiNikeshN,
pubmed-author:GupteRavindra DRD,
pubmed-author:JadhavMahesh GMG,
pubmed-author:KumarSanjayS,
pubmed-author:NemmaniKumar V SKV,
pubmed-author:RoychowdhuryAbhijitA,
pubmed-author:SharmaSomeshS,
pubmed-author:TannuAditi AAA,
pubmed-author:VishwakarmaRam ARA,
pubmed-author:YewalkarNilambariN
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2949-52
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19409777-Acrylamides,
pubmed-meshheading:19409777-Animals,
pubmed-meshheading:19409777-Cell Line, Tumor,
pubmed-meshheading:19409777-Colitis, Ulcerative,
pubmed-meshheading:19409777-Disease Models, Animal,
pubmed-meshheading:19409777-Humans,
pubmed-meshheading:19409777-Mice,
pubmed-meshheading:19409777-Nitriles,
pubmed-meshheading:19409777-Protein Kinase Inhibitors,
pubmed-meshheading:19409777-Protein Kinases,
pubmed-meshheading:19409777-Pyridines,
pubmed-meshheading:19409777-TOR Serine-Threonine Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors.
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pubmed:affiliation |
Department of Medicinal Chemistry, Piramal Life Sciences, 1-Nirlon Complex, Goregaon (E), Mumbai, India.
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pubmed:publicationType |
Journal Article
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