Linked Life Data

19409054

Source:http://linkedlifedata.com/resource/pubmed/id/19409054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-6-22
pubmed:abstractText
Stochastic event synchrony is a technique to quantify the similarity of pairs of signals. First, events are extracted from the two given time series. Next, one tries to align events from one time series with events from the other. The better the alignment, the more similar the two time series are considered to be. In Part I, the companion letter in this issue, one-dimensional events are considered; this letter concerns multidimensional events. Although the basic idea is similar, the extension to multidimensional point processes involves a significantly more difficult combinatorial problem and therefore is nontrivial. Also in the multidimensional case, the problem of jointly computing the pairwise alignment and SES parameters is cast as a statistical inference problem. This problem is solved by coordinate descent, more specifically, by alternating the following two steps: (1) estimate the SES parameters from a given pairwise alignment; (2) with the resulting estimates, refine the pairwise alignment. The SES parameters are computed by maximum a posteriori (MAP) estimation (step 1), in analogy to the one-dimensional case. The pairwise alignment (step 2) can no longer be obtained through dynamic programming, since the state space becomes too large. Instead it is determined by applying the max-product algorithm on a cyclic graphical model. In order to test the robustness and reliability of the SES method, it is first applied to surrogate data. Next, it is applied to detect anomalies in EEG synchrony of mild cognitive impairment (MCI) patients. Numerical results suggest that SES is significantly more sensitive to perturbations in EEG synchrony than a large variety of classical synchrony measures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0899-7667
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2203-68
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Quantifying statistical interdependence by message passing on graphs-part II: multidimensional point processes.
pubmed:affiliation
Laboratory for Information and Decision Systems, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. jdauwels@mit.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't