Source:http://linkedlifedata.com/resource/pubmed/id/19408098
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2009-10-8
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| pubmed:abstractText |
Several polymorphisms in apolipoprotein A1 (APOA1) gene have been associated with metabolic diseases. Increased transcription efficiency was observed in -75A allele carriers compared to -75G allele homozygotes. +83C allele was associated with higher body mass index and waist-to-hip ratio in type II diabetes subjects. -75G/A and +83C/T polymorphisms were analyzed by RFLP-PCR in 334 individuals from a Brazilian elderly cohort. APOA1 polymorphisms were associated with age-related morbidities, as well as with triglycerides, total cholesterol, HDL, VLDL, LDL, creatinine, urea, albumin, glycated hemoglobin and fasting glucose serum levels. Allele frequencies were 0.102 and 0.21, respectively, for -75A and +83T. -75G allele showed significant association with hypertension (P = 0.001). An association between +83C allele and obesity was observed (P = 0.040) and this allele also showed an association with hypertension in the presence of cardiovascular disease (P = 0.047). Moreover, +83T allele was associated with lower glycated hemoglobin values (P = 0.026). To our knowledge, there is no data associating this polymorphism with glycated hemoglobin. Furthermore, individuals carrying AT haplotype have lower risk for developing hypertension (P = 0.0002), while GT haplotype carriers present decreased risk to develop obesity comparing to GC haplotype (P = 0.025). APOA1 polymorphisms analysis may be a useful tool to identify risk factors for subjects and families and clarify the physiopathological role of these polymorphisms in age-related diseases, such as hypertension and obesity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
|
| pubmed:issn |
1591-9528
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| pubmed:author |
pubmed-author:AraujoLara QuirinoLQ,
pubmed-author:BurbanoRommel RodriguezRR,
pubmed-author:CendorogloMaysa SeabraMS,
pubmed-author:ChenElizabeth SuchiES,
pubmed-author:FuruyaTatiane KatsueTK,
pubmed-author:MazzottiDiego RoblesDR,
pubmed-author:RamosLuiz RobertoLR,
pubmed-author:de Arruda Cardoso SmithMaríliaM
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| pubmed:issnType |
Electronic
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| pubmed:volume |
9
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
319-25
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| pubmed:meshHeading |
pubmed-meshheading:19408098-Aged,
pubmed-meshheading:19408098-Aged, 80 and over,
pubmed-meshheading:19408098-Alleles,
pubmed-meshheading:19408098-Apolipoprotein A-I,
pubmed-meshheading:19408098-Body Mass Index,
pubmed-meshheading:19408098-Brazil,
pubmed-meshheading:19408098-Cardiovascular Diseases,
pubmed-meshheading:19408098-Cholesterol,
pubmed-meshheading:19408098-Cohort Studies,
pubmed-meshheading:19408098-Female,
pubmed-meshheading:19408098-Gene Frequency,
pubmed-meshheading:19408098-Haplotypes,
pubmed-meshheading:19408098-Humans,
pubmed-meshheading:19408098-Hypertension,
pubmed-meshheading:19408098-Male,
pubmed-meshheading:19408098-Middle Aged,
pubmed-meshheading:19408098-Obesity,
pubmed-meshheading:19408098-Polymerase Chain Reaction,
pubmed-meshheading:19408098-Polymorphism, Genetic,
pubmed-meshheading:19408098-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:19408098-Risk Factors,
pubmed-meshheading:19408098-Triglycerides
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| pubmed:year |
2009
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| pubmed:articleTitle |
Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity.
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| pubmed:affiliation |
Disciplina de Genética, Departamento de Morfologia e Genética, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Botucatu, 740, Edifício Leitão da Cunha-1 andar, São Paulo, SP, CEP 04023-900, Brazil.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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