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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-5-1
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pubmed:abstractText |
P. gingivalis is a major pathogen that is involved in the onset and progression of periodontal disease. This study investigated the effect of resveratrol, a naturally occurring polyphenol, on P. gingivalis LPS-accelerated vascular inflammation, a key step in the progression of periodontitis. Resveratrol significantly inhibited the P. gingivalis LPS-induced adhesion of leukocytes to endothelial cells and to the aortic endothelium by down-regulating the cell adhesion molecules, ICAM-1 and VCAM-1. Moreover, the inhibition of the P. gingivalis LPS-induced cell adhesion molecules by resveratrol was mainly mediated by nuclear factor-kappaB (NF-kappaB). Resveratrol suppressed P. gingivalis LPS-stimulated IkappaBalpha phosphorylation and nuclear translocation of the p65 subunit of NF-kappaB in HMECs. Overall, these findings suggest that resveratrol significantly attenuates the P. gingivalis LPS-induced monocyte adhesion to the endothelium by suppressing the expression of the NF-kappaB-dependent cell adhesion molecules, suggesting its therapeutic role in periodontal pathogen-induced vascular inflammation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/RELA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Stilbenes,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/resveratrol
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0253-6269
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pubmed:author |
pubmed-author:BaeMoon-KyoungMK,
pubmed-author:BaeSoo-KyungSK,
pubmed-author:JangHye-OckHO,
pubmed-author:JeongSeong-KyoonSK,
pubmed-author:JinSeong-DeokSD,
pubmed-author:KimKyu-WonKW,
pubmed-author:KimSu-RyunSR,
pubmed-author:KimWoo-SikWS,
pubmed-author:KooTae HyeonTH,
pubmed-author:ParkHyun-JooHJ,
pubmed-author:YunIlI
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
583-91
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pubmed:meshHeading |
pubmed-meshheading:19407977-Animals,
pubmed-meshheading:19407977-Anti-Inflammatory Agents,
pubmed-meshheading:19407977-Cell Adhesion,
pubmed-meshheading:19407977-Dose-Response Relationship, Drug,
pubmed-meshheading:19407977-Endothelial Cells,
pubmed-meshheading:19407977-Humans,
pubmed-meshheading:19407977-I-kappa B Proteins,
pubmed-meshheading:19407977-Intercellular Adhesion Molecule-1,
pubmed-meshheading:19407977-Leukocytes,
pubmed-meshheading:19407977-Lipopolysaccharides,
pubmed-meshheading:19407977-Male,
pubmed-meshheading:19407977-Phosphorylation,
pubmed-meshheading:19407977-Porphyromonas gingivalis,
pubmed-meshheading:19407977-RNA, Messenger,
pubmed-meshheading:19407977-Rats,
pubmed-meshheading:19407977-Rats, Sprague-Dawley,
pubmed-meshheading:19407977-Stilbenes,
pubmed-meshheading:19407977-Transcription, Genetic,
pubmed-meshheading:19407977-Transcription Factor RelA,
pubmed-meshheading:19407977-U937 Cells,
pubmed-meshheading:19407977-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2009
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pubmed:articleTitle |
Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression by suppressing NF-kappaB activation.
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pubmed:affiliation |
School of Dentistry, Pusan National University, Pusan, 602-739, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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