Linked Life Data

19405539

Source:http://linkedlifedata.com/resource/pubmed/id/19405539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2009-6-16
pubmed:abstractText
We find that the sensitivity of gramicidin A channels to the anesthetic halothane is highly lipid dependent. Specifically, exposure of membranes made of lamellar DOPC to halothane in concentrations close to clinically relevant reduces channel lifetimes by 1 order of magnitude. At the same time, gramicidin channels in membranes of nonlamellar DOPE are affected little, if at all, by halothane. We attribute this difference in channel behavior to a difference in the stress of lipid packing into a planar lipid bilayer, wherein the higher stress of DOPE packing reduces the degree of halothane partitioning into the hydrophobic interior.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1520-4995
pubmed:author
pubmed:issnType
Electronic
pubmed:day
23
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5501-3
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Lipid-dependent effects of halothane on gramicidin channel kinetics: a new role for lipid packing stress.
pubmed:affiliation
National Center for Medical Rehabilitation Research, National Institutes of Health,Bethesda, Maryland 20892, USA. weinricm@mail.nih.gov
pubmed:publicationType
Journal Article, Research Support, N.I.H., Intramural