Linked Life Data

19404544

Source:http://linkedlifedata.com/resource/pubmed/id/19404544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-4-30
pubmed:abstractText
Many serious thrombotic and haemorrhagic diseases or fatalities have been documented in human being exposed to microgravity or hypergravity environments, such as crewmen in space, roller coaster riders, and aircrew subjected to high-G training. Some possible related organs have been examined to explore the mechanisms underlying these gravity change-related diseases. However, the role of platelets which are the primary players in both thrombosis and haemostasis is unknown. Here we show that platelet aggregation induced by ristocetin or collagen and platelet adhesion to von Willebrand factor (VWF) were significantly decreased after platelets were exposed to simulated microgravity. Conversely, these platelet functions were increased after platelets were exposed to hypergravity. The tail bleeding time in vivo was significantly shortened in mice exposed to high-G force, whereas, was prolonged in hindlimb unloaded mice. Furthermore, three of 23 mice died after 15 minutes of -8 Gx stress. Platelet thrombi disseminated in the heart ventricle and blood vessels in the brain, lung, and heart from the dead mice. Finally, glycoprotein (GP) Ibalpha surface expression and its association with the cytoskeleton were significantly decreased in platelets exposed to simulated microgravity, and obviously increased in hypergravity-exposed platelets. These data indicate that the platelet functions are inhibited in microgravity environments, and activated under high-G conditions, suggesting a novel mechanism for gravity change-related haemorrhagic and thrombotic diseases. This mechanism has important implications for preventing and treating gravity change-related diseases, and also suggests that special attentions should be paid to human actions under different gravity conditions.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0340-6245
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
902-10
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:19404544-Adenosine Diphosphate, pubmed-meshheading:19404544-Animals, pubmed-meshheading:19404544-Blood Platelets, pubmed-meshheading:19404544-Collagen, pubmed-meshheading:19404544-Cytoskeleton, pubmed-meshheading:19404544-Hemorrhage, pubmed-meshheading:19404544-Hemostasis, pubmed-meshheading:19404544-Hindlimb Suspension, pubmed-meshheading:19404544-Humans, pubmed-meshheading:19404544-Hypergravity, pubmed-meshheading:19404544-Membrane Glycoproteins, pubmed-meshheading:19404544-Membrane Proteins, pubmed-meshheading:19404544-Mice, pubmed-meshheading:19404544-Models, Animal, pubmed-meshheading:19404544-P-Selectin, pubmed-meshheading:19404544-Platelet Adhesiveness, pubmed-meshheading:19404544-Platelet Aggregation, pubmed-meshheading:19404544-Ristocetin, pubmed-meshheading:19404544-Space Flight, pubmed-meshheading:19404544-Thrombosis, pubmed-meshheading:19404544-Time Factors, pubmed-meshheading:19404544-Weightlessness Simulation, pubmed-meshheading:19404544-von Willebrand Factor
pubmed:year
2009
pubmed:articleTitle
Effects of microgravity and hypergravity on platelet functions.
pubmed:affiliation
Department of Biological Science and Technology, Beijing University of Aeronautics and Astronautics, 37 Xueyuan Road, Haidian district, Beijing 100083, China. kdai@buaa.edu.cn
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't