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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-7-9
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pubmed:abstractText |
Tropical calcific pancreatitis (TCP) is a relatively common form of chronic pancreatitis in parts of Asia and Africa. The SPINK1 variant p.N34S is strongly associated with TCP, but other genetic factors remain to be defined. Chymotrypsinogen C (CTRC) degrades trypsinogen and loss-of-function variants have been found in European patients with chronic pancreatitis. Preliminary data indicate that CTRC might increase the risk for TCP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1473-5687
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
889-94
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pubmed:meshHeading |
pubmed-meshheading:19404200-Adolescent,
pubmed-meshheading:19404200-Adult,
pubmed-meshheading:19404200-Calcinosis,
pubmed-meshheading:19404200-Carrier Proteins,
pubmed-meshheading:19404200-Case-Control Studies,
pubmed-meshheading:19404200-Child,
pubmed-meshheading:19404200-Child, Preschool,
pubmed-meshheading:19404200-Chymotrypsinogen,
pubmed-meshheading:19404200-Female,
pubmed-meshheading:19404200-Genetic Predisposition to Disease,
pubmed-meshheading:19404200-Genetic Variation,
pubmed-meshheading:19404200-Humans,
pubmed-meshheading:19404200-India,
pubmed-meshheading:19404200-Male,
pubmed-meshheading:19404200-Middle Aged,
pubmed-meshheading:19404200-Pancreatitis, Chronic,
pubmed-meshheading:19404200-Serine Endopeptidases,
pubmed-meshheading:19404200-Trypsinogen,
pubmed-meshheading:19404200-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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