Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1991-12-11
|
| pubmed:abstractText |
We examined the distribution of peroxisome-specific membrane polypeptides (PMPs) among peroxisomes of the liver, renal cortex, and jejunal mucosa, using antibodies for 70 KD, 26 KD and 22 KD PMPs. Immunoblot analysis showed signals for 70 KD polypeptide in all three kinds of tissue, but for the other two only in the liver and renal cortex, with neither being detected in jejunal mucosa. The total amounts of PMPs increased in all three organs with DEHP (di-(2-ethylhexyl)phthalate) administration. By immunoelectron microscopic analysis using protein A-gold, the three PMPs were localized along the peroxisomal membrane. Quantitation of the gold particles associated with the peroxisomal membrane showed an increase in the density of 70 KD and 26 KD PMPs but a decrease in 22 KD PMP with the administration of DEHP. The presence of tissue-specific localizations of PMPs suggest the 70 KD PMP is a common constituent of peroxisomes of these three tissues, whereas 26 KD and 22 KD PMPs are absent in microperoxisomes of jejunal mucosal epithelium.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Abcd3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Diethylhexyl Phthalate,
http://linkedlifedata.com/resource/pubmed/chemical/Gold,
http://linkedlifedata.com/resource/pubmed/chemical/Immune Sera,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-1554
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1357-66
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1940307-ATP-Binding Cassette Transporters,
pubmed-meshheading:1940307-Animals,
pubmed-meshheading:1940307-Diethylhexyl Phthalate,
pubmed-meshheading:1940307-Gold,
pubmed-meshheading:1940307-Immune Sera,
pubmed-meshheading:1940307-Immunoblotting,
pubmed-meshheading:1940307-Immunohistochemistry,
pubmed-meshheading:1940307-Intestinal Mucosa,
pubmed-meshheading:1940307-Intracellular Membranes,
pubmed-meshheading:1940307-Jejunum,
pubmed-meshheading:1940307-Kidney Cortex,
pubmed-meshheading:1940307-Liver,
pubmed-meshheading:1940307-Male,
pubmed-meshheading:1940307-Membrane Proteins,
pubmed-meshheading:1940307-Microbodies,
pubmed-meshheading:1940307-Microscopy, Immunoelectron,
pubmed-meshheading:1940307-Molecular Weight,
pubmed-meshheading:1940307-Rats,
pubmed-meshheading:1940307-Rats, Inbred Strains
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Immunoelectron microscopic evidence for organ differences in the composition of peroxisome-specific membrane polypeptides among three rat organs: liver, kidney, and small intestine.
|
| pubmed:affiliation |
Department of Anatomy, Shinshu University School of Medicine, Matsumoto, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|