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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-30
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291951,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291952,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291953,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291954,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291955,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291956,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291957,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291958,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291959,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB291960,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB443623,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB443624,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB443625,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB443626,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB443627
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pubmed:abstractText |
Hepatitis E virus (HEV) genotype 3, which usually causes asymptomatic infection in Japan, induced severe hepatitis in 8 patients. To better understand genetic features of HEV associated with increased virulence, we determined the complete or near-complete nucleotide sequences of HEV from these 8 patients and from 5 swine infected with genotype 3 strain swJ19. Phylogenetic analysis showed that the isolates from the 8 patients and the 5 swine grouped separately from the other genotype 3 isolates to create a unique cluster, designated JIO. The human JIO-related viruses encoded 18 amino acids different from those of the other HEV genotype 3 strains. One substitution common to almost all human HEV strains in the JIO cluster was located in the helicase domain (V239A) and may be associated with increased virulence. A zoonotic origin of JIO-related viruses is suspected because the isolates from the 5 swine also possessed the signature V239A substitution in helicase.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-10092008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-10982322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-11504536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-11546856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-11546875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-12655086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-12907011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-14555851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-15567444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-15985017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-15994825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-16257426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-16257427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-16482537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-16971172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-17329696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-7844387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-9430591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19402955-9482438
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1080-6059
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pubmed:author |
pubmed-author:AbeNatsumiN,
pubmed-author:KawakamiManriM,
pubmed-author:MatsudaHiroyukiH,
pubmed-author:MishiroShunjiS,
pubmed-author:MiyakawaYuzoY,
pubmed-author:MochidaSatoshiS,
pubmed-author:OkamotoHiroakiH,
pubmed-author:SakugawaHiroshiH,
pubmed-author:SuginoshitaYoshikiY,
pubmed-author:TakahashiKazuakiK,
pubmed-author:WatanabeSeishiroS,
pubmed-author:YamamotoKazuhideK
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pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
704-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19402955-Aged,
pubmed-meshheading:19402955-Amino Acid Sequence,
pubmed-meshheading:19402955-Animals,
pubmed-meshheading:19402955-Female,
pubmed-meshheading:19402955-Genotype,
pubmed-meshheading:19402955-Hepatitis, Viral, Animal,
pubmed-meshheading:19402955-Hepatitis E,
pubmed-meshheading:19402955-Hepatitis E virus,
pubmed-meshheading:19402955-Humans,
pubmed-meshheading:19402955-Japan,
pubmed-meshheading:19402955-Male,
pubmed-meshheading:19402955-Middle Aged,
pubmed-meshheading:19402955-Molecular Sequence Data,
pubmed-meshheading:19402955-Phylogeny,
pubmed-meshheading:19402955-Sequence Analysis, DNA,
pubmed-meshheading:19402955-Swine,
pubmed-meshheading:19402955-Swine Diseases,
pubmed-meshheading:19402955-Virulence,
pubmed-meshheading:19402955-Zoonoses
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pubmed:year |
2009
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pubmed:articleTitle |
Virulent strain of hepatitis E virus genotype 3, Japan.
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pubmed:affiliation |
Toshiba General Hospital, Tokyo, Japan. kazuaki6.takahashi@po.toshiba.co.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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