Source:http://linkedlifedata.com/resource/pubmed/id/19402215
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2009-4-28
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| pubmed:abstractText |
Eighteen patients (12 men and 6 women) with aplastic anemia and active fungal infections (10 proven/probable; 8 possible) underwent stem cell transplantation using fludarabine combined with cyclophosphamide or total body irradiation. Peripheral blood stem cells (PBSC) were the main graft source and a combination of cyclosporine with either methotrexate or methylprednisolone was used for graft versus host disease prophylaxis. Fourteen patients (77.8%) achieved neutrophil engraftment after a median time of 11 d, while four died of fungal sepsis. Resolution of fungal infection occurred in 60% of patients with proven/probable infections and in 100% with possible fungal infections. At a median follow up of 30 months, 11 patients (61.1%) were alive and well. Fludarabine-based conditioning regimens with PBSC transplantation can be used successfully in patients with aplastic anemia and fungal infections.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1399-0012
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
228-32
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| pubmed:dateRevised |
2010-11-10
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| pubmed:meshHeading |
pubmed-meshheading:19402215-Adolescent,
pubmed-meshheading:19402215-Adult,
pubmed-meshheading:19402215-Anemia, Aplastic,
pubmed-meshheading:19402215-Antifungal Agents,
pubmed-meshheading:19402215-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19402215-Combined Modality Therapy,
pubmed-meshheading:19402215-Cyclophosphamide,
pubmed-meshheading:19402215-Female,
pubmed-meshheading:19402215-Graft Survival,
pubmed-meshheading:19402215-Graft vs Host Disease,
pubmed-meshheading:19402215-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:19402215-Humans,
pubmed-meshheading:19402215-Male,
pubmed-meshheading:19402215-Mycoses,
pubmed-meshheading:19402215-Retrospective Studies,
pubmed-meshheading:19402215-Risk Factors,
pubmed-meshheading:19402215-Survival Rate,
pubmed-meshheading:19402215-Transplantation, Homologous,
pubmed-meshheading:19402215-Transplantation Conditioning,
pubmed-meshheading:19402215-Vidarabine,
pubmed-meshheading:19402215-Whole-Body Irradiation,
pubmed-meshheading:19402215-Young Adult
|
| pubmed:articleTitle |
Fludarabine-based reduced intensity conditioning regimens for allogeneic hematopoietic stem cell transplantation in patients with aplastic anemia and fungal infections.
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| pubmed:affiliation |
Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India. biju@cmcvellore.ac.in
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| pubmed:publicationType |
Journal Article
|