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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-1-18
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pubmed:abstractText |
Left inferior frontal gyrus (IFG) is a critical neural substrate for the resolution of proactive interference (PI) in working memory. We hypothesized that left IFG achieves this by controlling the influence of familiarity- versus recollection-based information about memory probes. Consistent with this idea, we observed evidence for an early (200 msec)-peaking signal corresponding to memory probe familiarity and a late (500 msec)-resolving signal corresponding to full accrual of trial-related contextual ("recollection-based") information. Next, we applied brief trains of repetitive transcranial magnetic stimulation (rTMS) time locked to these mnemonic signals, to left IFG and to a control region. Only early rTMS of left IFG produced a modulation of the false alarm rate for high-PI probes. Additionally, the magnitude of this effect was predicted by individual differences in susceptibility to PI. These results suggest that left IFG-based control may bias the influence of familiarity- and recollection-based signals on recognition decisions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-10080370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-12457757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-14659494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-15758048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-15772360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-15788702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-16135552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-16135758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-16148241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-16157284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-16337090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-16724763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-17001274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-17357795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-17675110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-17928441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-17945512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19400678-18353682
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1530-8898
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-30
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pubmed:dateRevised |
2011-10-19
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pubmed:meshHeading |
pubmed-meshheading:19400678-Adult,
pubmed-meshheading:19400678-Electric Stimulation,
pubmed-meshheading:19400678-Electroencephalography,
pubmed-meshheading:19400678-Female,
pubmed-meshheading:19400678-Functional Laterality,
pubmed-meshheading:19400678-Humans,
pubmed-meshheading:19400678-Individuality,
pubmed-meshheading:19400678-Magnetic Resonance Imaging,
pubmed-meshheading:19400678-Male,
pubmed-meshheading:19400678-Memory, Short-Term,
pubmed-meshheading:19400678-Mental Recall,
pubmed-meshheading:19400678-Neuropsychological Tests,
pubmed-meshheading:19400678-Prefrontal Cortex,
pubmed-meshheading:19400678-Psychomotor Performance,
pubmed-meshheading:19400678-Reaction Time,
pubmed-meshheading:19400678-Recognition (Psychology),
pubmed-meshheading:19400678-Transcranial Magnetic Stimulation,
pubmed-meshheading:19400678-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Prefrontal control of familiarity and recollection in working memory.
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pubmed:affiliation |
University of Wisconsin, Madison, USA. e.feredoes@ucl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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