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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-5-6
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pubmed:abstractText |
We have developed a new class of diarylalkyl amides as novel TRPV1 antagonists. They exhibited potent (45)Ca(2+) uptake inhibitions in rat DRG neuron. In particular, the amide 59 was identified as a potent antagonist with IC(50) of 57 nM. The synthesis and structure-activity relationship of the diarylalkyl amides are also described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:JeongYeon-SuYS,
pubmed-author:KimHee-DooHD,
pubmed-author:KimNam-JungNJ,
pubmed-author:KimSun-YoungSY,
pubmed-author:KwonDo-YeonDY,
pubmed-author:LiFu-NanFN,
pubmed-author:MinKyung HoonKH,
pubmed-author:PaekSeung-MannSM,
pubmed-author:ParkHyeung-GeunHG,
pubmed-author:ParkYoung-HoYH,
pubmed-author:SuhYoung-GerYG
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3557-67
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pubmed:meshHeading |
pubmed-meshheading:19398205-Amides,
pubmed-meshheading:19398205-Animals,
pubmed-meshheading:19398205-Calcium,
pubmed-meshheading:19398205-Cells, Cultured,
pubmed-meshheading:19398205-Drug Design,
pubmed-meshheading:19398205-Inhibitory Concentration 50,
pubmed-meshheading:19398205-Rats,
pubmed-meshheading:19398205-Rats, Sprague-Dawley,
pubmed-meshheading:19398205-Structure-Activity Relationship,
pubmed-meshheading:19398205-Sulfonamides,
pubmed-meshheading:19398205-TRPV Cation Channels,
pubmed-meshheading:19398205-Tetrahydronaphthalenes
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pubmed:year |
2009
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pubmed:articleTitle |
Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists.
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pubmed:affiliation |
College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
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pubmed:publicationType |
Journal Article
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