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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-5-14
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pubmed:abstractText |
The parathyroid calcium receptor determines parathyroid hormone secretion and the response of parathyroid hormone gene expression to serum Ca2+ in the parathyroid gland. Serum Ca2+ regulates parathyroid hormone gene expression in vivo post-transcriptionally affecting parathyroid hormone mRNA stability through the interaction of trans-acting proteins to a defined cis element in the parathyroid hormone mRNA 3'-untranslated region. These parathyroid hormone mRNA binding proteins include AUF1 which stabilizes and KSRP which destabilizes the parathyroid hormone mRNA. There is no parathyroid cell line; therefore, we developed a parathyroid engineered cell using expression vectors for the full-length human parathyroid hormone gene and the human calcium receptor.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1741-7007
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19397786-Calcium,
pubmed-meshheading:19397786-Cell Line,
pubmed-meshheading:19397786-Gene Expression Regulation,
pubmed-meshheading:19397786-Heterogeneous-Nuclear Ribonucleoprotein D,
pubmed-meshheading:19397786-Immunoprecipitation,
pubmed-meshheading:19397786-Parathyroid Hormone,
pubmed-meshheading:19397786-Protein Binding,
pubmed-meshheading:19397786-Protein Processing, Post-Translational,
pubmed-meshheading:19397786-RNA, Messenger,
pubmed-meshheading:19397786-Receptors, Calcium-Sensing
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pubmed:year |
2009
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pubmed:articleTitle |
The calcium-sensing receptor regulates parathyroid hormone gene expression in transfected HEK293 cells.
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pubmed:affiliation |
Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. hillelgalitzer@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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