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pubmed-article:19397268pubmed:abstractTextHighly potent N-substituted delta-lactams have been rationally designed and synthesized by a concise route with a one-pot tandem reaction as key step. These iminosugars show weak inhibition of wild-type beta-glucocerebrosidase but 3- to 6-fold increases in mutant enzyme activity (N370S).lld:pubmed
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pubmed-article:19397268pubmed:articleTitleRational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.lld:pubmed
pubmed-article:19397268pubmed:affiliationState Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China.lld:pubmed
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